Fatal Cholestatic Liver Injury during Treatment with PD1 Immune Checkpoint Inhibitor for Malignant Melanoma: A Case Report

被引：12
|
作者：
Thorsteinsdottir, Thuridur [1 ]
Loitegard, Teje [2 ]
Reims, Henrik Mikael [3 ]
Porojnicu, Alina Carmen [1 ]
机构：
[1] Vestre Viken HF, Dept Oncol, Wergelands Gate 10, NO-3019 Drammen, Norway
[2] Vestre Viken HF, Dept Gastroenterol, Drammen, Norway
[3] Oslo Univ Hosp, Rikshosp, Dept Pathol, Oslo, Norway
来源：
CASE REPORTS IN ONCOLOGY | 2020年 / 13卷 / 02期
关键词：
Immune checkpoint inhibitors; Vanishing bile duct syndrome; Malignant melanoma;
D O I：
10.1159/000507695
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The use of immune checkpoint inhibitors has dramatically improved the chance of surviving malignant melanomas; however, the effect comes at the cost of toxicities that are difficult to predict. Immune-mediated hepatitis is the most common form of liver toxicity, but fatal outcome is uncommon. We report the case of a 70-year-old female with metastatic malignant melanoma who developed severe liver toxicity characterized by bile duct injury and cholestasis. The condition progressed despite potent immunosuppressive treatment, plasmapheresis, and intensive supportive care; and the patient died while still having tumor response.
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收藏
页码：659 / 663
页数：5
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