Binding of Submaximal C1q to B Cells Opsonized with Anti-CD20 Mabs Ofatumumab (OFA) or Rituximab (RTX) Promotes Complement Dependent Cytotoxicity (CDC), and Considerably Higher Levels of CDC Are Induced by OFA Than by RTX

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作者
Taylor, Ronald P. [1 ]
Pawhiczkowycz, Andrew W. [1 ]
Lindorfer, Margaret A. [1 ]
de Winkel, Jan G. J. van [2 ,3 ]
Beurskens, Frank J. [2 ]
Parren, Paul W. H. I. [2 ]
机构
[1] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA
[2] Genmab BV, Utrecht, Netherlands
[3] UMCU, Dept Immunol, Utrecht, Netherlands
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R5 [内科学];
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1002 ; 100201 ;
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页码:560 / 560
页数:1
相关论文
共 2 条
  • [1] Binding of Submaximal C1q Promotes Complement-Dependent Cytotoxicity (CDC) of B Cells Opsonized with Anti-CD20 mAbs Ofatumumab (OFA) or Rituximab (RTX): Considerably Higher Levels of CDC Are Induced by OFA than by RTX
    Pawluczkowycz, Andrew W.
    Beurskens, Frank J.
    Beum, Paul V.
    Lindorfer, Margaret A.
    van de Winkel, Jan G. J.
    Parren, Paul W. H. I.
    Taylor, Ronald P.
    JOURNAL OF IMMUNOLOGY, 2009, 183 (01): : 749 - 758
  • [2] Quantitative analyses reveal substantial differences between Ofatumumab (OFA) and Rituximab (RTX) in mediating Complement-Dependent Cytotoxicity (CDC) of B cell lines and Chronic Lymphocytic Leukemia (CLL) cells
    Taylor, P.
    MOLECULAR IMMUNOLOGY, 2011, 48 (14) : 1711 - 1712