Rash, Hepatotoxicity and Hyperbilirubinemia Among Kenyan Infants Born to HIV-infected Women Receiving Triple-antiretroviral Drugs for the Prevention of Mother-to-child HIV Transmission

被引：4

作者：

Minniear, Timothy D. ^{[1
,2
]}

Zeh, Clement ^{[2
,3
]}

Polle, Nicholas ^{[4
]}

Masaba, Rose ^{[3
]}

Peters, Philip J. ^{[2
]}

Oyaro, Boaz ^{[3
]}

Akoth, Benta ^{[3
]}

Ndivo, Richard ^{[3
]}

Angira, Frank ^{[3
]}

Mills, Lisa A. ^{[2
,3
]}

Thomas, Timothy K. ^{[2
,3
]}

机构：

[1] CDC, Epidem Intelligence Serv, Atlanta, GA 30333 USA

[2] CDC, Div HIV AIDS Prevent, Atlanta, GA 30333 USA

[3] Kenya Med Res Inst CDC Res & Publ Hlth Collaborat, Kisumu, Kenya

[4] Minist Hlth Kenya, Nairobi, Kenya

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2012年 / 31卷 / 11期

关键词：

HIV; antiretroviral agents; toxicity; infant; newborn; BREAST-MILK;

D O I：

10.1097/INF.0b013e318267ef6a

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared adverse events among breast-feeding neonates born to Kenyan mothers receiving triple-antiretroviral therapy, including either nevirapine or nelfinavir. Nevirapine-exposed infants had an absolute increase in the risk of rash but no significant risk differences for hepatotoxicity or high-risk hyperbilirubinemia compared with nelfinavir-exposed infants. From an infant-safety perspective, nevirapine-based regimens given during pregnancy and breast-feeding are viable options where alternatives to breast milk are not safe, affordable or feasible.

引用

页码：1155 / 1157

页数：3

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