Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress

被引：11

作者：

Han, Ying-Hao ^{[1
,9
]}

Kwon, Taeho ^{[1
,8
]}

Kim, Sun-Uk ^{[1
,2
]}

Ha, Hye-Lin ^{[1
]}

Lee, Tae-Hoon ^{[1
,3
]}

Kim, Jin-Man ^{[4
]}

Jo, Eun-Kyeong ^{[5
]}

Kim, Bo Yeon ^{[6
,7
]}

Yoon, Do Young ^{[8
]}

Yu, Dae-Yeul ^{[1
]}

机构：

[1] KRIBB, Aging Res Ctr, Taejon 305806, South Korea

[2] KRIBB, Natl Primate Res Ctr Korea, Taejon 305806, South Korea

[3] Chonnam Natl Univ, Dent Sci Res Inst, Dept Biochem, Kwangju 500757, South Korea

[4] Chungnam Natl Univ, Dept Pathol, Coll Med, Taejon 301747, South Korea

[5] Chungnam Natl Univ, Dept Microbiol, Coll Med, Taejon 301747, South Korea

[6] Korea Res Inst Biosci & Biotechnol, Chem Biol Res Ctr, Cheongwon 363883, South Korea

[7] Korea Res Inst Biosci & Biotechnol, World Class Inst, Cheongwon 363883, South Korea

[8] Konkuk Univ, Bio Mol Informat Ctr, Dept Biosci & Biotechnol, Seoul 143701, South Korea

[9] Heilongjiang Bayi Agr Univ DaQing, Coll Life Sci & Technol, Daqing 163319, Heilongjiang Pr, Peoples R China

来源：

BMB REPORTS | 2012年 / 45卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Heinz body; Hemolytic anemia; Macrophage; Peroxiredoxin; Phagocytosis; HYDROGEN-PEROXIDE; MAMMALIAN PEROXIREDOXIN; PRDX1; MICE; ERYTHROCYTE; ACTIVATION; PROTEINS; ISOFORMS; DEATH;

D O I：

10.5483/BMBRep.2012.45.10.082

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of peroxiredoxin (Prx) I as an erythrocyte antioxidant defense in red blood cells (RBCs) is controversial. Here we investigated the function of Prx I by using Prx I-/- and Prx I/II-/- mice. Prx I-/- mice exhibited a normal blood profile. However, Prx I-/- mice showed more significantly increased Heinz body formation as compared with Prx II-/- mice. The clearance rate of Heinz body-containing RBCs in Prx I-/- mice decreased significantly through the treatment of aniline hydrochloride (AH) compared with wild-type mice. Prx I deficiency decreased the phagocytic capacity of macrophage in clearing Heinz body-containing RBCs. Our data demonstrate that Prx I deficiency did not cause hemolytic anemia, but showed that further increased hemolytic anemia symptoms in Prx II-/- mice by attenuating phagocytic capacity of macrophage in oxidative stress damaged RBCs, suggesting a novel role of Pi, I in phagocytosis of macrophage. [BMB Reports 2012; 45(10): 560-564]

引用

页码：560 / 564

页数：5

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