Dystroglycan and AMP Kinase: Polarity's Protectors when the Power Goes Out

被引：26
|
作者：
Zhang, Li [1 ]
Seo-Mayer, Patricia [1 ]
Caplan, Michael J. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06525 USA
来源：
DEVELOPMENTAL CELL | 2009年 / 16卷 / 01期
关键词：
ACTIVATED PROTEIN-KINASE; LKB1; CELLS;
D O I：
10.1016/j.devcel.2008.12.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The AMP-stimulated protein kinase regulates epithelial polarity under conditions of energy depletion by phosphorylating the myosin regulatory light chain. In this issue of Developmental Cell, Mirouse et al. demonstrate that dystroglycan and perlecan, an extracellular matrix receptor and its ligand, help localize myosin regulatory light chain, making it available for phosphorylation by AMP kinase in response to energy stress.
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页码：1 / 2
页数：2
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