Anti-HIV activity of quassinoids

被引：45

作者：

Okano, M

Fukamiya, N

Tagahara, K

Cosentino, M

Lee, TTY

MorrisNatschke, S

Lee, KH

机构：

[1] HIROSHIMA UNIV,FAC INTEGRATED ARTS & SCI,DEPT INTERDISCIPLINARY STUDIES NAT ENVIRONM,HIGASHIHIROSHIMA 739,JAPAN

[2] KOBE PHARMACEUT UNIV,FAC PHARMACEUT SCI,KOBE,HYOGO 658,JAPAN

[3] BIOTECH RES LABS INC,ROCKVILLE,MD 20850

[4] UNIV N CAROLINA,SCH MED,CHAPEL HILL,NC 27599

[5] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00096-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C (20) demonstrated the highest anti-HIV activity (EC(50) = 10.6 mu M) in the absence of cytotoxicity with a therapeutic index of >25.

引用

页码：701 / 706

页数：6

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