Some Peculiarities of Local Distribution of Multipotent Mesenchymal Stromal Cells after Their Injection into Intact Muscle Tissue in Experiment

被引：1
|
作者：
Maiborodin, I. V. [1 ]
Morozov, V. V. [1 ]
Anikeev, A. A. [1 ]
Maslov, R. V. [1 ]
Figurenko, N. F. [1 ]
Matveeva, V. A. [1 ]
Maiborodina, V. I. [2 ]
机构：
[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Div, Ctr New Med Technol, Novosibirsk, Russia
[2] Inst Mol Pathol & Pathomorphol, Lab Ultrastruct Bases Pathol, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 164卷 / 04期
关键词：
multipotent mesenchymal stromal cells; muscular tissue; inflammation; sclerosis macrophages; LIVER FIBROSIS; SCAR FORMATION;
D O I：
10.1007/s10517-018-4031-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Changes in the muscular tissue after subcutaneous injection of autologous bone marrow multipotent mesenchymal stromal cells transfected with GFP gene and additionally stained with cell membrane dye Vybrant CM-Dil in the projection of ligated femoral vein were studied by light microscopy with luminescence. Stromal cells injected through the skin can appear not only in the damaged tissue where acceleration of regeneration processes is required, but also in intact structures located in superficial or deeper layers. In intact muscular tissue, stromal cells spreading in the perivascular tissue initiate inflammation and migration of macrophages, activate and even trigger sclerotic processes due to differentiation into connective tissue cells (fibroblasts) and stimulation of proliferation and collagen synthesis by host fibroblasts. Injected multipotent mesenchymal stromal cells are gradually phagocytized by macrophages.
引用
收藏
页码：554 / 560
页数：7
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