RecQ and Fe-S helicases have unique roles in DNA metabolism dictated by their unwinding directionality, substrate specificity, and protein interactions

被引：19

作者：

Estep, Katrina N. ^{[1
]}

Brosh, Robert M., Jr. ^{[1
]}

机构：

[1] NIA, Lab Mol Gerontol, NIH, Biomed Res Ctr, 251 Bayview Blvd, Baltimore, MD 21224 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2018年 / 46卷

基金：

美国国家卫生研究院;

关键词：

WERNER-SYNDROME PROTEIN; BLOOMS-SYNDROME HELICASE; NUCLEOTIDE EXCISION-REPAIR; ROTHMUND-THOMSON-SYNDROME; G-QUADRUPLEX DNA; ANEMIA GROUP J; WARSAW BREAKAGE SYNDROME; SYNDROME GENE-PRODUCT; CHROMATID COHESION ESTABLISHMENT; STRAND-ANNEALING ACTIVITIES;

D O I：

10.1042/BST20170044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Helicases are molecular motors that play central roles in nucleic acid metabolism. Mutations in genes encoding DNA helicases of the RecQ and iron-sulfur (Fe-S) helicase families are linked to hereditary disorders characterized by chromosomal instabilities, highlighting the importance of these enzymes. Moreover, mono-allelic RecQ and Fe-S helicase mutations are associated with a broad spectrum of cancers. This review will discuss and contrast the specialized molecular functions and biological roles of RecQ and Fe-S helicases in DNA repair, the replication stress response, and the regulation of gene expression, laying a foundation for continued research in these important areas of study.

引用

页码：77 / 95

页数：19