Challenges with defining response to antitumor agents in pediatric neuro-oncology: A report from the response assessment in pediatric neuro-oncology (RAPNO) working group

被引：55

作者：

Warren, Katherine E. ^{[1
]}

Poussaint, Tina Y. ^{[2
]}

Vezina, Gilbert ^{[3
]}

Hargrave, Darren ^{[4
]}

Packer, Roger J. ^{[3
]}

Goldman, Stewart ^{[5
]}

Wen, Patrick Y. ^{[6
]}

Pollack, Ian F. ^{[7
]}

Zurakowski, David ^{[2
]}

Kun, Larry E. ^{[8
]}

Prados, Michael D. ^{[9
]}

Rutkowski, Stefan ^{[10
]}

Kieran, Mark W. ^{[11
]}

机构：

[1] NCI, Bethesda, MD 20892 USA

[2] Childrens Hosp, Boston, MA 02115 USA

[3] Childrens Natl Med Ctr, Washington, DC 20010 USA

[4] Great Ormond St Hosp Sick Children, London WC1N 3JH, England

[5] Lurie Childrens Hosp Chicago, Chicago, IL USA

[6] Dana Farber Canc Inst, Boston, MA 02115 USA

[7] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[8] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[9] Univ Calif San Francisco, San Francisco, CA 94143 USA

[10] Univ Med Ctr, Hamburg, Germany

[11] Dana Farber Childrens Hosp Canc Ctr, Boston, MA USA

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 09期

基金：

美国国家卫生研究院;

关键词：

brain; imaging; pediatric; RANO; response; tumor; INTEROBSERVER VARIABILITY; CHEMOTHERAPY; CHILDREN; GLIOMAS; CRITERIA; CARBOPLATIN; SURVIVAL; THERAPY;

D O I：

10.1002/pbc.24562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Criteria for new drug approval include demonstration of efficacy. In neuro-oncology, this is determined radiographically utilizing tumor measurements on MRI scans. Limitations of this method have been identified where drug activity is not reflected in decreased tumor size. The RANO (Response Assessment in Neuro-Oncology) working group was established to address limitations in defining endpoints for clinical trials in adult neuro-oncology and to develop standardized response criteria. RAPNO was subsequently established to address unique issues in pediatric neuro-oncology. The aim of this paper is to delineate response criteria issues in pediatric clinical trials as a basis for subsequent recommendations. Pediatr Blood Cancer 2013;60:1397-1401. (c) 2013 Wiley Periodicals, Inc.

引用

页码：1397 / 1401

页数：5

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