Heparin for Growth Factor Delivery Systems

被引：0

作者：

Ding Shanshan ^{[1
]}

Cui Yuanlu ^{[1
]}

Gong Zheng ^{[2
]}

Yin Yuji ^{[2
]}

Yao Kangde ^{[2
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Res Ctr Tradit Chinese Med, Engn Res Ctr Modern Chinese Med Discovery & Prepa, Minist Educ, Tianjin 300193, Peoples R China

[2] Tianjin Univ, Sch Mat Sci & Engn, Tianjin 300072, Peoples R China

来源：

PROGRESS IN CHEMISTRY | 2008年 / 20卷 / 12期

关键词：

heparin; growth factors; hydrogel; release; bioactivity;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Heparin, a sulfated polysaccharide and a representative antithrombotic drug, has special binding affinity with a number of biologically important proteins such as growth factors and cytokines, and thereby plays an essential role in the regulation of various biological signaling. Heparin-containing matrices or delivery systems immobilize and protect high-affinity heparin-binding growth factors from degradation, release growth factor in a sustained manner, and increase both the stability and activity of the growth factor. In this review, we summarize the recently developed hydrogel matrices and scaffolds which contain heparin for growth factor delivery in tissue engineering.

引用

页码：1998 / 2011

页数：14

共 61 条

[1] Delivery of basic fibroblast growth factor (bFGF) from photoresponsive hydrogel scaffolds
Andreopoulos, FM
Persaud, I
[J]. BIOMATERIALS, 2006, 27 (11) : 2468 - 2476
[2] Lack of evidence of an interaction between leu-enkephalin and muscarinic-like responses in the frog semicircular canal
Andrianov, GN
Ryzhova, IV
[J]. NEUROSIGNALS, 2003, 12 (06) : 310 - 314
[3] Heparin regulates vascular endothelial growth factor165-dependent mitogenic activity, tube formation, and its receptor phosphorylation of human endothelial cells -: Comparison of the effects of heparin and modified heparins
Ashikari- Hada, S
Habuchi, H
Kariya, Y
Kimata, K
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (36) : 31508 - 31515
[4] Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation
Benoit, DSW
Anseth, KS
[J]. ACTA BIOMATERIALIA, 2005, 1 (04) : 461 - 470
[5] Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor
Cai, SS
Liu, YC
Shu, XZ
Prestwich, GD
[J]. BIOMATERIALS, 2005, 26 (30) : 6054 - 6067
[6] Capila I, 2002, ANGEW CHEM INT EDIT, V41, P391
[7] Action of microparticles of heparin and alginate crosslinked gel when used as injectable artificial matrices to stabilize basic fibroblast growth factor and induce angiogenesis by controlling its release
Chinen, N
Tanihara, M
Nakagawa, M
Shinozaki, K
Yamamoto, E
Mizushima, Y
Suzuki, Y
[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2003, 67A (01): : 61 - 68
[8] CHRISTIAN N, 2005, CHEM BIOL, V12, P731
[9] Heparin immobilized porous PLGA microspheres for angiogenic growth factor delivery
Chung, Hyun Jung
Kim, Hong Kee
Yoon, Jun Jin
Park, Tae Gwan
[J]. PHARMACEUTICAL RESEARCH, 2006, 23 (08) : 1835 - 1841
[10] The effect of heparin on the gellation of Pluronic F-127 hydrogel
Chung, Yong-Il
Lee, Seung-Young
Tae, Giyoong
[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2006, 284 (480-484) : 480 - 484

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