Progesterone receptor agonists and antagonists

被引：6
|
作者：
Allan, G [1 ]
Macielag, M [1 ]
机构：
[1] RW Johnson Pharmaceut Res Inst, Raritan, NJ 08869 USA
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 1999年 / 9卷 / 07期
关键词：
contraception; endometriosis; leiomyomata; mifepristone; progestin;
D O I：
10.1517/13543776.9.7.955
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Steroidal progestin agonists have long been used in oral contraceptives, and the progestin antagonist mifepristone is used as an abortifacient. Progestin antagonists are also likely to be useful for treating breast cancer and various gynaecological disorders. This patent review relates to progestin receptor agonists and antagonists, focusing on applications filed over the past three years. Two emerging themes will be elaborated upon: the development of novel steroidal and non-steroidal compounds, and the elucidation of new therapeutic uses for progestin antagonists.
引用
收藏
页码：955 / 962
页数：8
相关论文
共 50 条
  • [1] Progesterone Receptor Agonists and Antagonists as Anticancer Agents
    Chakraborty, A.
    Chatterjee, S.
    Roy, P.
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2010, 10 (06) : 506 - 517
  • [2] Triterpenes from Alisma orientalis act as androgen receptor agonists, progesterone receptor antagonists, and glucocorticoid receptor antagonists
    Lin, Hsiang-Ru
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (15) : 3626 - 3632
  • [3] Progesterone receptor isoforms, agonists and antagonists differentially reprogram estrogen signaling
    Singhal, Hari
    Greene, Marianne E.
    Zarnke, Allison L.
    Laine, Muriel
    Al Abosy, Rose
    Chang, Ya-Fang
    Dembo, Anna G.
    Schoenfelt, Kelly
    Vadhi, Raga
    Qiu, Xintao
    Rao, Prakash
    Santhamma, Bindu
    Nair, Hareesh B.
    Nickisch, Klaus J.
    Long, Henry W.
    Becker, Lev
    Brown, Myles
    Greene, Geoffrey L.
    ONCOTARGET, 2018, 9 (04) : 4282 - 4300
  • [4] Progesterone receptor antagonists
    Spitz, Irving M.
    CURRENT OPINION IN INVESTIGATIONAL DRUGS, 2006, 7 (10) : 882 - 890
  • [5] Progesterone antagonists and progesterone receptor modulators
    Spitz, IM
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2003, 12 (10) : 1693 - 1707
  • [6] Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line
    Fitzpatrick, SL
    Berrodin, TJ
    Jenkins, SF
    Sindoni, DM
    Deecher, DC
    Frail, DE
    ENDOCRINOLOGY, 1999, 140 (09) : 3928 - 3937
  • [7] Novel mechanisms of progesterone antagonists and progesterone receptor
    Edwards, DP
    Leonhardt, SA
    Gass-Handel, E
    JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 2000, 7 (01) : S22 - S24
  • [8] Progesterone antagonists and progesterone receptor modulators: an overview
    Spitz, IM
    STEROIDS, 2003, 68 (10-13) : 981 - 993
  • [9] Novel Mechanisms of Progesterone Antagonists and Progesterone Receptor
    Dean P. Edwards
    Susan A. Leonhardt
    Elizabeth Gass-Handel
    The Journal of the Society for Gynecologic Investigation: JSGI, 2000, 7 : S22 - S24
  • [10] Muscarinic receptor agonists and antagonists
    Zlotos, DP
    Bender, W
    Holzgrabe, U
    EXPERT OPINION ON THERAPEUTIC PATENTS, 1999, 9 (08) : 1029 - 1053
12345