Molecular motion in nanochannels: Single molecule evidence and multiscale simulation

Nanotechnology are providing tools of practical interest for many applications such as bioanalyitc, drug delivery devices. Indeed there is need to clarify molecular motion in nanometric space. We addressed this topic performing a single molecule fluorescence technique, Fluorescence Correlation Spectroscopy of polymeric particles and chains in glass etched channels characterized by having one dimension in the nanoscale range. The experimental set up was then simulated in silico trough a mesoscale modeling approach. Here the first results of molecular nano-constrained motion are shown.