Synthesis of Dimethylphosphinyl-substituted α-Amino(aryl)methylphosphonic Acids and Their Esters

被引：4
|
作者：
Zagraniarsky, Yulian [1 ]
Ivanova, Bojidarka [1 ]
Nikolov, Karamfil [1 ]
Varbanov, Sabi [2 ]
Cholakova, Tsvetanka [1 ]
机构：
[1] Univ Sofia, Fac Chem, Sofia 1164, Bulgaria
[2] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2008年 / 63卷 / 10期
关键词：
Dimethylphosphinyl-substituted Phosphonates and alpha-Aminophosphonic Acids; Kabachnik-Fields Reaction; Imine Hydrophosphonylation;
D O I：
10.1515/znb-2008-1009
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Dimethylphosphinylmethylamine (1) and its aldimines 2 Were used for the preparation of dimethyl and diethyl alpha-amino(aryl)methylphosphonates 3a-1 via imine hydrophosphonylation and Kabachnik-Fields reaction. Their acid hydrolysis gave rise to the corresponding alpha-aminophosphonic acids 4a-e. Compounds 3 and 4 have two different phosphorus-containing groups-phosphonyl and dimethylphosphinyl-and might have interesting biological activity.
引用
收藏
页码：1192 / 1198
页数：7
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