3-(Adamantan-1-yl)-4-hydroxybenzyl Substituted Purines and Pyrimidines: Synthesis and Cytotoxic Activity

被引：0
|
作者：
Kode, Nageswara Rao [1 ]
Devangachinta, Dakshinamurthy [1 ]
Phadtare, Shashikant [1 ]
机构：
[1] Xavier Univ Louisiana, Coll Pharm, Div Basic Pharmaceut Sci, New Orleans, LA 70125 USA
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2012年 / 9卷 / 10期
关键词：
Adamantan-1-yl-methylphenol; Cytotoxic activity; 2,6,9-substituted purines; 1,4,5-substituted pyrimidines;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Selected adamantanyl purines and pyrimidines 1-10 were synthesized. These compounds were evaluated for cytotoxic activity against NCI-60 DTP human tumor cell line screen. N-9-(3'-Adamantan-1-yl)-4'-hydroxy(benzyl)-2-amino-6-chloropurine, 3 and N-9-[(3'-(Adamantan-1-yl)-4'-(2 '',3 '',4 ''-trifluorobenzyloxy)]benzyl-2-amino-6-chloropurine, 6 elicited significant cytotoxic activity with GI50 values in the 1-10 mu M range for selected human tumor cell lines. While other compounds elicited moderate activity with GI50 values in the 10-20 mu M range for most human tumor cell lines.
引用
收藏
页码：926 / 933
页数：8
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