Synthesis, characterisation and biological studies of CuII and ZnII metal complexes with drug lorazepam [7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepine-2-one]

被引：0

作者：

Gautam, P ^{[1
]}

Sharma, N ^{[1
]}

Chaturvedi, K ^{[1
]}

Chaturvedi, GK ^{[1
]}

机构：

[1] Coll Agr, Chem Lab, Agra 282002, Uttar Pradesh, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2006年 / 83卷 / 03期

关键词：

lorazepam; copper(II) complexes; zinc(II) complexes;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1 : 1 complexes of Cu-II and Zn-II with drug lorazepam having general formula [ML(NO3)(2).2H(2)O] have been synthesized and characterized on the basis of elemental analysis, IR and thermal studies. Analytical and IR data suggest that both complexes are monomeric due to coordination by N(1) and N(4) atoms. The ligand and complexes have been screened for their antimicrobial activities. Antimicrobial studies suggest that the Cu-II complex is more toxic than Zn-II complex.

引用

页码：269 / 271

页数：3

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