Facile construction of luminescent supramolecular assemblies with aggregation-induced emission feature through supramolecular polymerization and their biological imaging

Supramolecular polymerization is a novel method for the fabrication of multifunctional polymeric composites that mainly relied on the non-covalent interactions between different components. In this work, a novel and facile strategy has been developed for the construction of fluorescent organic nanoparticles (FONs) with aggregation -induced emission (AIE) characteristic based on the host-guest interaction between beta cyclodextrin terminating polyethylene glycol (beta-CD-PEG) and adamantine (Ad) containing AIE dye (Ph-Ad). Through the host-guest interaction, the fluorescent amphiphiles can be facilely obtained. The characterization results suggested we have successfully prepared the AIE-active FONs through the supramolecular polymerization. The Ph-Ad/beta-CD-PEG FONs possess many advantages such small size, high water dispersibility, desirable fluorescence properties, low cytotoxicity and efficient cell dyeing performance. All of the above results implied that these AIE-active supramolecular assemblies should be promising luminescent probes with great potential for different biomedical applications.