A novel five-way translocation t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) involving Ph chromosome in a patient of chronic myeloid leukemia: a case report

被引：11
|
作者：
Yokota, Sho [1 ,2 ]
Nakamura, Yuichi [1 ]
Bessho, Masami [1 ]
机构：
[1] Saitama Med Univ Hosp, Dept Hematol, Moroyama, Saitama 3500495, Japan
[2] Tachikawa Sougo Hosp, Dept Hematol, Tokyo 1908578, Japan
来源：
MOLECULAR CYTOGENETICS | 2012年 / 5卷
关键词：
CML; Variant Ph translocation; Five-way translocation; CHRONIC MYELOCYTIC-LEUKEMIA; CHRONIC-MYELOGENOUS-LEUKEMIA; IN-SITU HYBRIDIZATION; PHILADELPHIA-CHROMOSOME; CML; REARRANGEMENT; IMATINIB;
D O I：
10.1186/1755-8166-5-20
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
About 5-10 % of chronic myelogenous leukemia (CML) patients show variant Philadelphia (Ph) translocations. The formation mechanisms and clinical significance of variant Ph translocations remain unclear. We report a CML case with a novel five-way complex translocation. Although the result of initial G-banding was 46,XY,t(7;11;9)(q22;q13;q34),t(9;22)(q34;q11.2), fluorescence in situ hybridization (FISH) demonstrated t(7;11;9;22;9)(q22;q13;q34;q11.2;q34) consisting of sequential rearrangements involving five chromosomes. The patient was successfully treated by imatinib and obtained a major molecular response. To our knowledge, this is the tenth CML case with a complicated Ph translocation involving five chromosomes and the third one treated by imatinib. Good response with imatinib therapy suggested that a single-event rearrangement was involved in the chromosomal changes.
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页数：5
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