Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells

被引：13
|
作者：
Luo, Fu-Cheng [1 ]
Feng, Yue-Mei [1 ]
Zhao, Lu [1 ]
Li, Kui [1 ]
Wang, Sheng-Dong [1 ]
Song, Jun-Ying [1 ]
Bai, Jie [1 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Med, Kunming 650500, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2012年 / 523卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Morphine; Thioredoxin-1; Opioid receptor; MU-OPIOID RECEPTOR; NF-KAPPA-B; PLACE PREFERENCE; WITHDRAWAL SYNDROME; OXIDATIVE STRESS; REDOX REGULATION; ERK PATHWAY; MICE; ACTIVATION; DEPENDENCE;
D O I：
10.1016/j.neulet.2012.06.039
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Attempts are being made to identify genes targeted by morphine. It is beneficial for developing new treatments that alleviate side-effects of morphine. Thioredoxin-1 is a small ubiquitous protein that has various biological activities, such as the control of redox balance, the inhibition of apoptosis and the modulation of inflammation. In this study, we found that thioredoxin-1 was induced by morphine in SH-SY5Y cells. Furthermore, opioid receptor. PI3K and ERK pathways were involved in morphine-induced increase of thioredoxin-1 expression. These results suggest that thioredoxin-1 maybe play a role in the actions of morphine. More detailed analysis could clarify cellular and molecular mechanisms involved in the actions of morphine. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：50 / 55
页数：6
相关论文
共 50 条
  • [1] Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells
    Bai, Liping
    Zhang, Se
    Zhou, Xiaoshuang
    Li, Ye
    Bai, Jie
    BIOCHIMIE, 2019, 160 : 55 - 60
  • [2] Characterization of gene expression regulated by Panax ginseng in SH-SY5Y cells
    Hak-Jae Kim
    Sung Wook Kang
    Mi-Ja Kim
    Young-Ock Kim
    Geum-soog Kim
    Yoon Hyung Park
    Joo-Ho Chung
    Molecular & Cellular Toxicology, 2010, 6 : 219 - 227
  • [3] Characterization of gene expression regulated by Panax ginseng in SH-SY5Y cells
    Kim, Hak-Jae
    Kang, Sung Wook
    Kim, Mi-Ja
    Kim, Young-Ock
    Kim, Geum-soog
    Park, Yoon Hyung
    Chung, Joo-Ho
    MOLECULAR & CELLULAR TOXICOLOGY, 2010, 6 (03) : 219 - 227
  • [4] Endogenous Morphine in SH-SY5Y Cells and the Mouse Cerebellum
    Muller, Arnaud
    Glattard, Elise
    Taleb, Omar
    Kemmel, Veronique
    Laux, Alexis
    Delalande, Francois
    Roussel, Guy
    Van Dorsselaer, Alain
    Metz-Boutigue, Marie-Helene
    Aunis, Dominique
    Goumon, Yannick
    PLOS ONE, 2008, 3 (02):
  • [5] Changes in SH-SY5Y cells and tau protein after morphine
    Lew, GM
    JOURNAL OF NEUROCHEMISTRY, 1996, 66 : S63 - S63
  • [6] Involvement of endothelin in morphine tolerance in neuroblastoma (SH-SY5Y) cells
    Bhalla, Shaifali
    Ciaccio, Natalie
    Wang, Zaijie Jim
    Gulati, Anil
    EXPERIMENTAL BIOLOGY AND MEDICINE, 2006, 231 (06) : 1152 - 1156
  • [7] Characterization of Src and EGFR protein expression in chronic morphine treated SH-SY5Y cells
    Randell, Kesa
    Prenus, Rose
    Goodman, Carl B.
    FASEB JOURNAL, 2013, 27
  • [8] Expression levels of OPRM1 and PDYN in human SH-SY5Y cells treated with morphine and methadone
    Saify, Khyber
    Saadat, Mostafa
    LIFE SCIENCES, 2016, 150 : 39 - 41
  • [9] Inhibition of Parkin or PINK1 Expression in SH-SY5Y Dopaminergic Cells Increases SH-SY5Y Sensitivity to Paraquat Induced Cytotoxicity
    Ornelas, Loren
    Pulst, Stefan M.
    Huynh, Duong P.
    NEUROLOGY, 2009, 72 (11) : A490 - A490
  • [10] The role of reactive oxygen species in morphine addiction of SH-SY5Y cells
    Ma, Jun
    Yuan, Xuan
    Qu, Hengyi
    Zhang, Juan
    Wang, Dong
    Sun, Xiling
    Zheng, Qiusheng
    LIFE SCIENCES, 2015, 124 : 128 - 135
12345