Flow Chemistry, Continuous Processing, and Continuous Manufacturing: A Pharmaceutical Perspective

被引：73
|
作者：
May, Scott A. [1 ]
机构：
[1] Eli Lilly & Co, Small Mol Design & Dev, Indianapolis, IN 46285 USA
来源：
JOURNAL OF FLOW CHEMISTRY | 2017年 / 7卷 / 3-4期
关键词：
Flow chemistry; continuous processing; continuous manufacturing; PFR; CSTR; pharmaceutical; API; steady state; state of control; control strategy; drug substance; drug product (DP); SCALE-UP; ANNULATED PYRIDINES; MEDICINAL CHEMISTRY; CHEMICAL-SYNTHESIS; SELF-OPTIMIZATION; PLATFORM; TECHNOLOGY; GENERATION; INHIBITORS; REACTOR;
D O I：
10.1556/1846.2017.00029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Flow chemistry has become a vibrant area for research over the past decade. This perspective is intended to capture insights on how these advances have and will continue to impact the development and commercialization of active pharmaceutical ingredients. A series of chemistry examples from a number of pharmaceutical companies will highlight the influence of flow chemistry on this industry.
引用
收藏
页码：137 / 145
页数：9
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