Trihexyphenidyl treatment of clozapine-induced hypersalivation

被引：49
|
作者：
Spivak, B
Adlersberg, S
Rosen, L
Gonen, N
Mester, R
Weizman, A
机构：
[1] TEL AVIV UNIV,SACKLER FAC MED,IL-69978 TEL AVIV,ISRAEL
[2] BEILINSON MED CTR,GEHA PSYCHIAT HOSP,IL-49100 PETAH TIQWA,ISRAEL
[3] RABIN MED CTR,FELSENSTEIN MED RES CTR,PETAH TIQWA,ISRAEL
来源：
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY | 1997年 / 12卷 / 04期
关键词：
clozapine; hypersalivation; trihexyphenidyl;
D O I：
10.1097/00004850-199707000-00005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of this study was to investigate the efficacy of the anticholinergic agent trihexyphenidyl in the treatment of clozapine-induced hypersalivation. Fourteen chronic schizophrenic patients who exhibited nocturnal hypersalivation during clozapine treatment were coadministered trihexyphenidyl (5-15 mg/day, at bedtime) for 15 days. Salivation was assessed by a single-item 5-point scale. A reduction of 44% in the reported nocturnal hypersalivation was observed after trihexyphenidyl treatment. These results indicate that at least some chronic schizophrenic patients with clozapine-induced nocturnal hypersalivation may benefit from anticholinergic treatment.
引用
收藏
页码：213 / 215
页数：3
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