Isolation and identification of a major urinary canthaxanthin metabolite in rats

被引：14
|
作者：
Bausch, J [1 ]
Liechti, H [1 ]
Oesterhelt, G [1 ]
Kistler, A [1 ]
机构：
[1] F Hoffmann La Roche Ltd, CH-4070 Basel, Switzerland
来源：
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH | 1999年 / 69卷 / 04期
关键词：
carotenoids; canthaxanthin; metabolism; urinary metabolite; rat;
D O I：
10.1024/0300-9831.69.4.268
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The urinary metabolic pattern after administration of the radiolabeled non-provitamin A carotenoid canthaxanthin was investigated in rats. In the rather complex HPLC urinary metabolic pattern a fraction was found which was conjugated. Deconjugation of the polar conjugates with glusulase, purification of the metabolite with HPLC and identification with GC-MS and NMR revealed that it was 3-hydroxy-4-oxo-7,8-dihydro-beta-ionone. This structure was confirmed by comparisons with HPLC retention times, UV/VIS- and NMR-spectroscopy and GC-MS of the synthesized compound.
引用
收藏
页码：268 / 272
页数：5
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