Evolution and function of de novo originated genes

被引:24
|
作者
Wu, Dong-Dong [1 ]
Zhang, Ya-Ping [1 ]
机构
[1] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
基金
中国国家自然科学基金;
关键词
De novo origin; New gene; Evolution; DROSOPHILA-YAKUBA; DARK-MATTER; EXPRESSION; MICRORNAS; SELECTION; YEAST; INSIGHTS; GENOME; DNA;
D O I
10.1016/j.ympev.2013.02.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
De novo origination has recently been appreciated to be an important mechanism contributing to the origin of genes. Evidence indicates that de novo originated genes can evolve important and even essential functions rapidly. We present an "adaptation following neutrality" process to explain the evolution of essential function of new genes. How new de novo originated genes become involved in pathways and interact with other old genes, and the exact functions of these new genes, however, remains largely undocumented. Examinations of the function of de novo origin and the function of noncoding RNA genes should become more frequent and appreciated in the future studies. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:541 / 545
页数:5
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