Ofloxacin once daily versus twice daily in community-acquired pneumonia and acute exacerbation of chronic bronchitis - A randomized multicenter study

被引：3
|
作者：
Rayman, J
Krchnavy, M
Balciar, P
Duchon, J
Fortunik, J
Faith, L
Manduchova, H
Drgona, L
Koren, P
Kraszko, I
Krcmery, V
机构：
[1] UNIV TRNAVA,DEPT MED,TRNAVA 91743,SLOVAKIA
[2] DEPT PNEUMOL,TRNAVA SUCHA NAD PARNOU,SLOVAKIA
[3] DEPT PNEUMOL,KOSICE,SLOVAKIA
[4] DEPT PNEUMOL,HNUSTA,SLOVAKIA
[5] DEPT PNEUMOL,ZILINA,SLOVAKIA
[6] DEPT PNEUMOL,HLOHOVEC,SLOVAKIA
[7] UNIV HOSP TRNAVA,TRNAVA,SLOVAKIA
[8] UNIV HOSP KOSICE,KOSICE,SLOVAKIA
[9] NATL INST PNEUMOL,PODUNAJSKE BISKUPICE,SLOVAKIA
[10] UNIV TRNAVA,DEPT MED,TRNAVA,SLOVAKIA
[11] UNIV TRNAVA,DEPT CHEMOTHERAPY,TRNAVA,SLOVAKIA
来源：
CHEMOTHERAPY | 1996年 / 42卷 / 03期
关键词：
ofloxacin; pneumonia; side effects; community-acquired pneumonia; chronic obstructive pulmonary disease;
D O I：
10.1159/000239447
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Eighty-two patients with community-acquired pneumonia (CAP) or acute exacerbation (AE) of chronic bronchitis were randomized to receive ofloxacin (OFL) 400 mg twice daily (39 Key Words patients) versus 400 mg once daily (43 patients) orally. Cure Ofloxacin rates showed no statistically significant difference (90.1 vs. Pneumonia 94.6%), but more patients receiving 800 mg/day had side effects, Thus, the once daily administration of OFL is equally effective and safer than 400 mg twice daily to treat CAP or AE chronic obstructive pulmonary disease, especially in countries with higher pneumococcal and Haemophilus influenzae resistance in community practice.
引用
收藏
页码：227 / 230
页数：4
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