The success and the challenge of all-trans retinoic acid in the treatment of cancer

被引：97

作者：

Ni, Xiaoling ^{[1
]}

Hu, Guohua ^{[1
]}

Cai, Xun ^{[2
,3
]}

机构：

[1] Fudan Univ, Shanghai Med Coll, Zhongshan Hosp, Dept Gen Surg, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Hematol, 197 Ruijin Rd 2, Shanghai 200025, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, State Key Lab Med Genom, 197 Ruijin Rd 2, Shanghai 200025, Peoples R China

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2019年 / 59卷 / sup1期

基金：

上海市自然科学基金;

关键词：

All-trans retinoic acid; acute promyelocytic leukemia; retinoic acid receptors; chemotherapy; epigenetic modifiers; differentiation; ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE MYELOID-LEUKEMIA; INOSINE MONOPHOSPHATE DEHYDROGENASE; INHIBITOR VALPROIC ACID; MULTICENTER PHASE-II; CELL LUNG-CANCER; BREAST-CANCER; RAR-ALPHA; ARSENIC TRIOXIDE; INDUCED DIFFERENTIATION;

D O I：

10.1080/10408398.2018.1509201

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

All-trans retinoic acid (ATRA), an active metabolite of vitamin A, plays important roles in cell proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA are mediated by nuclear retinoid receptors as well as non-genomic signal pathway, such as MAPK and PKA. The great success of differentiation therapy with ATRA in acute promyelocytic leukemia (APL) not only improved the prognosis of APL but also spurred the studies of ATRA in the treatment of other tumors. Since the genetic and physiopathological simplicity of APL is not common in human malignancies, the combination of ATRA with other agents (chemotherapy, epigenetic modifiers, and arsenic trioxide, etc) had been extensively investigated in a variety of tumors. In this review, we will discuss in details about ATRA and its role in cancer treatment.

引用

页码：S71 / S80

页数：10

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