Biosynthesis of fluoroacetate and 4-fluorothreonine by Streptomyces cattleya. The stereochemical processing of glycerol

被引：10
|
作者：
Nieschalk, J
Hamilton, JTG
Murphy, CD
Harper, DB
OHagan, D
机构：
[1] UNIV DURHAM, DEPT CHEM, SCI LABS, DURHAM DH1 3LE, ENGLAND
[2] QUEENS UNIV BELFAST, DEPT FOOD SCI, MICROBIAL BIOCHEM SECT, BELFAST BT9 5PX, ANTRIM, NORTH IRELAND
来源：
CHEMICAL COMMUNICATIONS | 1997年 / 08期
关键词：
D O I：
10.1039/a700498b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
When both (2R)-[1-H-2(2)]- and (2S)-[1-H-2(2)]-glycerol are incubated with resting cell suspensions of S. cattleya, only the 2R-enantiomer labels the fluoromethyl groups of fluoroacetate and 4-fluorothreonine, with retention of both deuterium atoms, placing metabolic and mechanistic limitations on the process of biological fluorination.
引用
收藏
页码：799 / 800
页数：2
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