MTNR1B common genetic variant is associated with type 2 diabetes mellitus risk

Background: Melatonin is a circadian rhythm regulator and any imbalance in its levels can be related to various metabolic disorders. The genetic variants of Melatonin Receptor 1B (MTNR1B) are reported to be associated with type 2 diabetes mellitus(T2DM) susceptibility. Purpose: To investigate the association of MTNR1B common variant, rs10830963 (C/G), with the risk of T2DM in a group of Iranian population. Methods: 187 T2DM (case) and 100 normal individuals (control) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: There were significant difference in frequency of genotypes and alleles of rs10830963 in patient and control groups (P = 0.003, P = 0.0008, respectively). The GG, CG genotypes and also G allele increased risk of T2DM disease (OR: 2.63, OR: 1.87, and OR: 1.90 respectively). Conclusion: Our finding could suggest that rs10830963 variant in the MTNR1B gene is associated with the development of T2DM in a group of Iranian population.