Detection of hepatitis B surface antigen, hepatitis B core antigen, and hepatitis B virus DNA in parotid tissues

被引:17
|
作者
Chen, Lizhang [1 ]
Liu, Fuqiang [1 ]
Fan, Xuegong [2 ]
Gao, Jianming [1 ]
Chen, Nengzhi [3 ]
Wong, Tom
Wu, Jun [4 ]
Wen, Shi Wu [1 ,5 ,6 ,7 ]
机构
[1] Cent S Univ, Sch Publ Hlth, Changsha 410083, Peoples R China
[2] Cent S Univ, Xiangya Hosp, Dept Infect Dis, Changsha 410083, Peoples R China
[3] Cent S Univ, Changde Hosp, Dept Surg, Changsha 410083, Peoples R China
[4] Publ Hlth Agcy Canada, CIDPC, Blood Safety Surveillance Div, Ottawa, ON, Canada
[5] Univ Ottawa, Dept Obstet & Gynecol, OMNI Res Grp, Ottawa, ON K1H 8L6, Canada
[6] Clin Epidemiol Program, Ottawa Hlth Res Inst, Ottawa, ON, Canada
[7] Univ Ottawa, Dept Epidemiol & Community Hlth, Ottawa, ON, Canada
关键词
Parotid tissue; HBsAg; HBcAg; HBV DNA; INFECTION; SALIVA; HBSAG;
D O I
10.1016/j.ijid.2008.03.015
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Objective: To examine the presence of hepatitis B surface antigen (HBsAg), hepatitis B core antigen (HBcAg), and hepatitis B virus (HBV) DNA in parotid tissues from patients with positive serum HBV markers. Methods: HBsAg and HBcAg were examined in parotid biopsy tissues from patients with suspected parotid tumor and positive serum HBV markers by immunocytochemistry, and HBV DNA was detected in parotid tissues by PCR. Results: Among the 22 patients with a parotid tumor, only one was pathologically confirmed as a neoplasm; all others were benign. HBsAg and HBcAg were present in parotid cells with positive rates of 45.5% (10/22) and 40.9% (9/22), respectively, with an overall positive rate of 54.5% (12/22). Of the 22 cases with serum markers of HBV infection, seven (31.8%) had both HBsAg and HBcAg in the parotid cells. HBV DNA was present in seven of the 12 samples in which hepatitis B antigen was detected (58.3%). Conclusions: HBV in saliva might originate from the infected salivary glands and the infectious saliva could transmit HBV. (C) 2008 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:20 / 23
页数:4
相关论文
共 50 条
  • [1] Hepatitis B virus DNA and hepatitis B surface antigen levels in chronic hepatitis B
    Fung, James
    Lai, Ching-Lung
    Yuen, Man-Fung
    [J]. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2010, 8 (06) : 717 - 726
  • [2] Hepatitis B core antigen and hepatitis B surface antigen in a patient with active hepatitis B and HIV
    Cardenas, A
    [J]. JOURNAL OF HEPATOLOGY, 2005, 42 (02) : 284 - 284
  • [3] Detection of hepatitis B virus DNA in tissues of hepatocellular carcinomas related to hepatitis C virus which are negative for hepatitis B virus surface antigen
    Sugawara, Y
    Makuuchi, M
    Takada, K
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1999, 34 (09) : 934 - 938
  • [4] Detection of hepatitis B virus surface antigen in hepatitis B vaccine recipients
    Chawla, YK
    Sharma, SK
    Saini, N
    Arora, L
    Masih, B
    Duseja, A
    Dhiman, RK
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (09): : S104 - S105
  • [5] Hepatitis B virus transmission by blood donation negative for hepatitis B surface antigen, antibody to HBsAg, antibody to hepatitis B core antigen and HBV DNA
    Dow, BC
    Peterkin, MA
    Green, RHA
    Cameron, SO
    [J]. VOX SANGUINIS, 2001, 81 (02) : 140 - 140
  • [6] Quantitative Hepatitis B e Antigen: A Better Predictor of Hepatitis B Virus DNA than Quantitative Hepatitis B Surface Antigen
    Hudu, Shuaibu A.
    Niazlin, Mohd T.
    Nordin, Syafinaz A.
    Saeed, Mohammed I.
    Tan, Soek S.
    Omar, Haniza
    Shahar, Hamiza
    Sekawi, Zamberi
    [J]. CLINICAL LABORATORY, 2018, 64 (04) : 443 - 449
  • [7] Hepatitis B virus DNA in relation to duration of hepatitis B surface antigen carriage
    Mendy, ME
    Fortuin, M
    Hall, AJ
    Jack, AD
    Whittle, HC
    [J]. BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 1999, 56 (01) : 34 - 38
  • [8] Detection of hepatitis B virus DNA in serum is rare in the absence of hepatitis B surface antigen: impacts for detection and monitoring of chronic hepatitis B
    Trevillyan, Janine M.
    Dennison, Amanda
    Jenney, Adam
    Spelman, Denis
    [J]. PATHOLOGY, 2014, 46 (01) : 69 - 71
  • [10] Expression of Hepatocyte Hepatitis B Core Antigen and Hepatitis B Surface Antigen as a Marker in the Management of Chronic Hepatitis B Patients
    Yim, Sun Young
    Kim, Tae Hyung
    Jun, Suh Sang
    Kim, Eun Sun
    Keum, Bora
    Seo, Yeon Seok
    Yim, Hyung Joon
    Jeen, Yoon Tae
    Chun, Hoon Jai
    Lee, Hong Sik
    Um, Soon Ho
    Kim, Chang Duck
    Won, Nam Hee
    Ryu, Ho Sang
    [J]. GUT AND LIVER, 2017, 11 (03) : 417 - 425