Comparison of electrically-Evoked Ganglion Cell Responses in Normal and Degenerate Retina

被引：10

作者：

Ye, Jang Hee ^{[1
]}

Kim, Kyung Hwan ^{[2
]}

Goo, Yong Sook ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Sch Med, Dept Physiol, Cheongju, South Korea

[2] Yonsei Univ, Coll Hlth Sci, Dept Biomed Engn, Wonju, South Korea

来源：

2008 30TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOLS 1-8 | 2008年

关键词：

retinal prosthesis; retinal ganglion cell; multi-electrode array (MEA); rd1; mouse;

D O I：

10.1109/IEMBS.2008.4649699

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Retinal prosthesis is regarded as a promising method for restoring vision for the blind with retinal diseases such as retinitis pigmentosa (RP) and age related macular degeneration (ARMD). Among the several prerequisites for retinal prosthesis to succeed, one of the most important factors is the optimization of electrical stimulation applied through the prosthesis. From the previous study, we showed that the electrical characteristics of diseased retina are different from those of normal retina. For the next step, we compared electrically evoked response properties of retinal ganglion cells and established the thresholds for charge density in normal and rd1 mouse using multi-electrode array (MEA). The threshold for charge density was higher in rd1 mouse. The mean values were 254.78 mu C/cm(2) and 424.62 mu C/cm(2) in normal and rd1 mouse, respectively.

引用

页码：2465 / +

页数：2

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