A new method for the synthesis of a phosphonic acid analogue of phosphoserine via a novel 1,1-difluorophosphonate intermediate

被引：8
|
作者：
Kawamoto, AM [1 ]
Campbell, MM [1 ]
机构：
[1] UNIV BATH,SCH CHEM,BATH BA2 7AY,AVON,ENGLAND
来源：
JOURNAL OF FLUORINE CHEMISTRY | 1997年 / 81卷 / 02期
关键词：
phosphoserine analogue; 1,1-difluorophosphane intermediate; synthesis;
D O I：
10.1016/S0022-1139(96)03516-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of [4,4-difluoro-4-(dihydroxyphosphinyl)-2-amino] butanoic acid, an analogue of phosphoserine, is reported by two different routes; one route gave a racemic mixture, and the other, by using the strategy of a coupling reaction with a chiral compound, gave a single enantiomer.
引用
收藏
页码：181 / 186
页数：6
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