LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?

被引：40
|
作者：
Taiana, Elisa [1 ,2 ]
Ronchetti, Domenica [1 ,2 ]
Todoerti, Katia [2 ]
Nobili, Lucia [1 ]
Tassone, Pierfrancesco [3 ]
Amodio, Nicola [3 ]
Neri, Antonino [1 ,2 ]
机构：
[1] Univ Milan, Dept Oncol & Hematooncol, I-20122 Milan, Italy
[2] Fdn Ca Granda IRCCS Policlin, Hematol, I-20122 Milan, Italy
[3] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy
来源：
NON-CODING RNA | 2020年 / 6卷 / 03期
关键词：
lncRNA; NEAT1; paraspeckle; DNA damage repair; cancer; neurodegenerative disease; LONG NONCODING RNA; STRAND BREAK REPAIR; CHROMATIN-REMODELING COMPLEXES; SPLICING-FACTOR; HOMOLOGOUS RECOMBINATION; BINDING PROTEINS; PAIRING PROTEIN; NUCLEAR-BODIES; HNRNP-K; P53;
D O I：
10.3390/ncrna6030026
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.
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页数：17
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