Severe lactic acidosis induced by nucleoside analogues in an HIV-infected man

被引：24
|
作者：
Roy, PM [1 ]
Gouello, JP [1 ]
Pennison-Besnier, I [1 ]
Chennebault, JM [1 ]
机构：
[1] Univ Hosp, Dept Emergency Med, Angers, France
来源：
ANNALS OF EMERGENCY MEDICINE | 1999年 / 34卷 / 02期
关键词：
D O I：
10.1016/S0196-0644(99)70244-1
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
Nucleoside analogues can induce myopathy or hepatitis by means of mitochondrial dysfunction. We report the case of a 31-year-old man infected with HIV who had a severe lactic acidosis without muscle or liver symptoms. He improved after hemodialysis and withdrawal of antiviral drugs. Muscle and liver evaluation allowed us to ascribe lactic acidosis to a mitochondriopathy induced by zidovudine and didanosine.
引用
收藏
页码：282 / 284
页数：3
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