Tolerance and morphine-induced cross-tolerance are not shown to Tyr-W-MIF-1 analgesia

被引：5
|
作者：
Bell, RL [1 ]
Vaccarino, AL
Olson, RD
Olson, GA
Nores, WL
Cambre, JG
Zadina, JE
Kastin, AJ
机构：
[1] Univ New Orleans, Dept Psychol, New Orleans, LA 70148 USA
[2] Tulane Univ, Sch Med, New Orleans, LA 70112 USA
[3] VA Med Ctr, New Orleans, LA 70112 USA
来源：
PEPTIDES | 1999年 / 20卷 / 08期
关键词：
peptide; opioid; Tyr-MIF-1; pain; nociception;
D O I：
10.1016/S0196-9781(99)00090-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tolerance and cross-tolerance between Tyr-W-MIF-1, a mixed mu-agonist/antagonist, and morphine were examined. Opiate dependence also was examined. Rats were pretreated with Tyr-W-MIF-1, morphine, or saline for 4 days. On day 5, the animals were tested for Tyr-W-MIF-1 analgesia, morphine analgesia, or naloxone-precipitated withdrawal. Tyr-W-MIF-1- and morphine-pretreated animals showed similar levels of dependence. Animals pretreated with Tyr-W-MIF-1 failed to express tolerance to Tyr-W-MIF-1 analgesia but did display cross-tolerance to morphine analgesia. Animals pretreated with morphine displayed tolerance to morphine analgesia but did not express cross-tolerance to Tyr-W-MIF-1 analgesia. Therefore. tolerance and morphine-induced cross-tolerance were not expressed to Tyr-W-MIF-1 analgesia. (C) 1999 Elsevier Science inc. All rights reserved.
引用
收藏
页码：971 / 978
页数：8
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