In Vitro Antiviral Activity of Heterophyllaea pustulata Extracts

被引：1

作者：

Konigheim, Brenda S. ^{[1
,2
]}

Beranek, Mauricio ^{[2
]}

Comini, Laura R. ^{[1
]}

Aguilar, Javier J. ^{[2
]}

Marioni, Juliana ^{[1
]}

Cabrera, Jose L. ^{[1
]}

Contigiani, Marta S. ^{[2
]}

Nunez Montoya, Susana C. ^{[1
]}

机构：

[1] Natl Univ Cordoba, Sch Chem, Dept Pharm, IMBIV CONICET, RA-5016 Cordoba, Argentina

[2] Natl Univ Cordoba, Sch Med, Inst Virol Dr JM Vanella, RA-5016 Cordoba, Argentina

来源：

NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 08期

关键词：

Antiviral; Antiherpetic activity; Anthraquinone extracts; Heterophyllaea pustulata; Cytotoxicity; Selectivity index; ANTHRAQUINONES; INFECTIONS; RESISTANCE; PLANTS; DRUGS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antiviral activity was tested of different polarity extracts, with differing chemical composition, obtained from aerial parts of Heterophyllaea pustulata Hook f. (Rubiaceae) against Herpes Simplex Virus Type I (HSV-1) and Saint Louis Encephalitis Virus (SLEV). The Vero cell line was employed as a host cell for the antiviral assessment of benzene (Ben), ethyl acetate (EtOAc) and ethanol (EtOH) extracts by means of the Neutral Red uptake assay and plaque reduction test. None of the extracts showed antiviral activity against SLEV. Only the extracts (Ben and EtOAc) with a high content of anthraquinones (AQs) inhibited HSV-1 replication, exhibiting Selectivity Index (SI) values of 2.7 and 2.4, respectively. Therefore, these extracts could be good candidates as natural sources for antiviral drug development against HSV-1.

引用

页码：1025 / 1028

页数：4

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