Radiotheranostics with radiolanthanides: Design, development strategies, and medical applications

被引：48
|
作者：
Mishiro, Kenji [1 ]
Hanaoka, Hirofumi [2 ]
Yamaguchi, Aiko [2 ]
Ogawa, Kazuma [1 ]
机构：
[1] Kanazawa Univ, Inst Frontier Sci Initiat, Kanazawa, Ishikawa 9201192, Japan
[2] Gunma Univ, Grad Sch Med, Dept Bioimaging Informat Anal, 3-39-22 Showa, Maebashi, Gunma 3718511, Japan
来源：
COORDINATION CHEMISTRY REVIEWS | 2019年 / 383卷
关键词：
TARGETED RADIONUCLIDE THERAPY; METASTATIC BONE PAIN; MONOCLONAL-ANTIBODY GIRENTUXIMAB; CARCINOEMBRYONIC ANTIGEN CEA; RESISTANT PROSTATE-CANCER; CYCLIC RGD PEPTIDE; IN-VIVO EVALUATION; PROOF-OF-CONCEPT; MEMBRANE ANTIGEN; PRECLINICAL EVALUATION;
D O I：
10.1016/j.ccr.2018.12.005
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
"Radiotheranostics" is a term used in nuclear medicine to refer to the use of radioisotope (RI)-labeled agents to perform simultaneous imaging and therapy of a target lesion. A radiotheranostics system uses radiolanthanides as diagnostic and therapeutic RIs. In this review, we discuss radiotheranostics with radiolanthanides, focusing on the design, development strategies, and medical applications of radiolanthanide-labeled probes. We also discuss the potential and future uses of radiolanthanides in radiotheranostics. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：104 / 131
页数：28
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