Effects of Cilnidipine on Serum Uric Acid Level and Urinary Nitrogen Monoxide Excretion in Patients with Hypertension

被引：5

作者：

Hamada, Toshihiro ^{[1
]}

Yamada, Kensaku ^{[2
]}

Mizuta, Einosuke ^{[3
]}

Watanabe, Arisa ^{[1
]}

Osaki, Tomohiro ^{[1
]}

Ishida, Katsunori ^{[1
]}

Hasegawa, Akira ^{[4
]}

Sakata, Shinji ^{[4
]}

Mishima, Mutsuo ^{[4
]}

Ogino, Kazuhide ^{[5
]}

Nosaka, Yoshihito ^{[6
]}

Miyazaki, Satoshi ^{[7
]}

Ohtahara, Akira ^{[3
]}

Ninomiya, Haruaki ^{[8
]}

Kato, Masahiko ^{[2
]}

Yoshida, Akio ^{[4
]}

Taniguchi, Shin-ichi ^{[1
]}

Yamamoto, Kazuhiro ^{[2
]}

Hisatome, Ichiro ^{[4
]}

机构：

[1] Tottori Univ, Fac Med, Dept Reg Med, Yonago, Tottori 6838503, Japan

[2] Tottori Univ, Fac Med, Div Mol Med & Therapeut, Yonago, Tottori 6838503, Japan

[3] Sanin Rosai Hosp, Dept Cardiovasc Med, Yonago, Tottori, Japan

[4] Tottori Univ, Inst Regenerat Med & Biofunct, Grad Sch Med Sci, Yonago, Tottori 6838503, Japan

[5] Tottori Univ Hosp, Ctr Clin Residency Program, Yonago, Tottori 6838503, Japan

[6] Nosaka Med Clin, Yonago, Tottori, Japan

[7] Nojima Hosp, Dept Cardiovasc Med, Kurayoshi, Japan

[8] Tottori Univ, Fac Med, Dept Biol Regulat, Yonago, Tottori 6838503, Japan

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2012年 / 34卷 / 07期

关键词：

cilnidipine; Ca2+ channel blockers; uric acid; nitrogen monoxide; hypertension; SYSTOLIC HYPERTENSION; RENAL-DISEASE; RISK; ALLOPURINOL; PROGRESSION;

D O I：

10.3109/10641963.2012.666600

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of cilnidipine on the serum uric acid level and urinary NO excretion in hypertensive patients were investigated. Blood and urine samples of 16 hypertensive outpatients were collected before and 2 months after cilnidipine therapy (10 mg). The serum uric acid level decreased significantly after cilnidipine treatment, while the uric acid-creatinine clearance ratio was unaffected. The cilnidipine medication produced a significant increase in urinary NO excretion, although amlodipine did not change it significantly. Therefore, cilnidipine has a profound antihypertensive effect and may reduce the serum uric acid level and increase NO production in the kidney.

引用

页码：470 / 473

页数：4

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