Serum levels of angiopoietin-2 are associated with the growth of multiple myeloma

被引：13
|
作者：
Pappa, Constantina A. [1 ]
Tsirakis, George [2 ]
Samiotakis, Panagiotis [3 ]
Tsigaridaki, Maria [3 ]
Alegakis, Athanasios [4 ]
Goulidaki, Nectaria [3 ]
Alexandrakis, Michael G. [2 ,3 ,4 ]
机构：
[1] Venizelion Hosp Heraklion, Dept Hematol, Iraklion, Crete, Greece
[2] Univ Hosp Heraklion, Dept Hematol, Iraklion 71110, Crete, Greece
[3] Univ Hosp Heraklion, Hematol Lab, Iraklion 71110, Crete, Greece
[4] Univ Crete, Sch Med, Iraklion, Crete, Greece
来源：
CANCER INVESTIGATION | 2013年 / 31卷 / 06期
关键词：
Angiogenesis; Myeloma; Growth factors; Receptors; BONE-MARROW; ANGIOGENIC CYTOKINES; RECEPTOR TIE-2; EXPRESSION; CELL; DISEASE; SURVIVAL; VEGF; INTERLEUKIN-6; VASCULATURE;
D O I：
10.3109/07357907.2013.800093
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Angiopoietins and their receptor, Tie-2, have crucial role in angiogenesis. We measured serum levels of angiopoietin-2 (Ang-2), soluble Tie-2, and factors of burden and prognosis in myeloma (LDH, CRP, beta-2 microglobulin, and interleukin-6) in 55 newly diagnosed patients, with 30 of them in plateau phase, in order to note correlations among them. Levels of Ang-2 were higher in patients in advanced stage of disease, decreased in plateau phase, and correlated with all other factors. Circulating Ang-2 in myeloma patients significantly correlated to factors of disease burden and prognosis, and therefore measuring its levels may be important for the valuation of the disease.
引用
收藏
页码：385 / 389
页数：5
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