Insight into the Roles of the 140-149 Catalytic Loop and the Zinc-Binding Domain for HIV-1 Integrase Activity

被引：0
|
作者：
Carayon, Kevin [1 ]
Na, Li [1 ]
Delelis, Olivier [1 ]
Simon, Francoise [1 ]
Mouscadet, Jean-Francois [1 ]
Mouscadet, Jean-Francois [1 ]
Brochon, Jean-Claude [1 ]
Deprez, Eric [1 ]
机构：
[1] CNRS, Cachan, France
来源：
BIOPHYSICAL JOURNAL | 2009年 / 96卷 / 03期
关键词：
D O I：
10.1016/j.bpj.2008.12.220
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
320-Pos
引用
收藏
页码：62A / 62A
页数：1
相关论文
共 50 条
  • [1] Structural and functional insight into molecular recognition of HIV-1 integrase catalytic loop
    Tchertanov, L.
    Delelis, O.
    Mouscadet, J.
    FEBS JOURNAL, 2007, 274 : 260 - 260
  • [2] The mobility of an HIV-1 integrase active site loop is correlated with catalytic activity
    Greenwald, J
    Le, V
    Butler, SL
    Bushman, FD
    Choe, S
    BIOCHEMISTRY, 1999, 38 (28) : 8892 - 8898
  • [3] Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity
    Zheng, RL
    Jenkins, TM
    Craigie, R
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) : 13659 - 13664
  • [4] Study of the Conformational Dynamics of the Catalytic Loop of WT and G140A/G149A HIV-1 Integrase Core Domain Using Reversible Digitally Filtered Molecular Dynamics
    Williams, Sarah L.
    Essex, Jonathan W.
    JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2009, 5 (02) : 411 - 421
  • [5] Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
    Cai, ML
    Zheng, RL
    Caffrey, M
    Craigie, R
    Clore, GM
    Gronenborn, AM
    NATURE STRUCTURAL BIOLOGY, 1997, 4 (07) : 567 - 577
  • [6] Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
    Mengli Cai
    Ronglan Zheng
    Michael Caffrey
    Robert Craigie
    G. Marius Clore
    Angela M. Gronenborn
    Nature Structural Biology, 1997, 4 : 567 - 577
  • [7] Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
    Nature Structural Biology, 1997, 4 : 839 - 840
  • [8] Molecular dynamics studies on the HIV-1 integrase catalytic domain
    Lins, RD
    Briggs, JM
    Straatsma, TP
    Carlson, HA
    Greenwald, J
    Choe, S
    McCammon, JA
    BIOPHYSICAL JOURNAL, 1999, 76 (06) : 2999 - 3011
  • [9] Integrase HIV-1: inhibition of catalytic activity by modified oligonucleotides
    Prikazchikova, T
    Mouscadet, JF
    Gottikh, M
    FEBS JOURNAL, 2005, 272 : 17 - 17
  • [10] BIOPHYSICAL AND ENZYMATIC-PROPERTIES OF THE CATALYTIC DOMAIN OF HIV-1 INTEGRASE
    HICKMAN, AB
    PALMER, I
    ENGELMAN, A
    CRAIGIE, R
    WINGFIELD, P
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1994, 269 (46) : 29279 - 29287
12345