Plasmacytoid dendritic cells and immunotherapy in multiple sclerosis

被引:1
|
作者
von Glehn, Felipe [2 ]
Santos, Leonilda M. [2 ]
Balashov, Konstantin E. [1 ]
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, New Brunswick, NJ 08901 USA
[2] Univ Estadual Campinas, Neuroimmunol Unit, Dept Genet Evolut & Bioagents, BR-13083970 Campinas, SP, Brazil
关键词
innate immunity; multiple sclerosis; plasmacytoid dendritic cells; Toll-like receptors; type I interferon; INTERFERON-PRODUCING CELLS; INHIBITS TLR9-MEDIATED ACTIVATION; CENTRAL-NERVOUS-SYSTEM; IFN-ALPHA PRODUCTION; SINGLE-STRANDED RNA; TOLL-LIKE RECEPTORS; REGULATORY T-CELLS; INDOLEAMINE 2,3-DIOXYGENASE; NUCLEIC-ACIDS; CUTTING EDGE;
D O I
10.2217/IMT.12.117
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Plasmacytoid dendritic cells (pDCs) are specialized APCs implicated in the pathogenesis of many human diseases. Compared with other peripheral blood mononuclear cells, pDCs express a high level of TLR9, which recognizes viral DNA at the initial phase of viral infection. Upon stimulation, these cells produce large amounts of type I interferon and other proinflammatory cytokines and are able to prime T lymphocytes. Thus, pDCs regulate innate and adaptive immune responses. This article reviews select aspects of pDC biology relevant to the disease pathogenesis and immunotherapy in multiple sclerosis. Many unresolved questions remain in this area, promising important future discoveries in pDC research.
引用
收藏
页码:1053 / 1061
页数:9
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