2,2-Bis(trifluoromethyl)-2,3-dihydro-1H-1,5-benzodiazepines

被引:1
|
作者
Petko, K. I. [1 ]
Vorobey, V. M. [1 ]
Gutov, A. V. [1 ]
Chernega, A. N. [1 ]
机构
[1] Natl Acad Sci Ukraine, Inst Organ Chem, UA-02660 Kiev, Ukraine
关键词
1,5-benzodiazepines; hexafluoroacetone N-phenylimines; X-ray structural analysis;
D O I
10.1007/s10593-013-1360-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A method for the cyclization of hexafluoroacetone N-phenylimine derivatives with the formation of benzodiazepine analogs containing trifluromethyl groups has been elaborated. The obtained compounds were characterized by the NMR and mass spectral analysis and by the data from X-ray structural analysis.
引用
收藏
页码:1172 / 1179
页数:8
相关论文
共 50 条
  • [1] 2,2-Bis(trifluoromethyl)-2,3-dihydro-1H-1,5-benzodiazepines
    K. I. Petko
    V. M. Vorobey
    A. V. Gutov
    A. N. Chernega
    Chemistry of Heterocyclic Compounds, 2013, 49 : 1172 - 1179
  • [2] The Facile Syntheses of 2,3-Dihydro-1H-1,5-benzodiazepines and Their Ribofuranosides
    Jain, Renuka
    Yadav, Tripti
    Kumar, Manoj
    Yadav, Ashok K.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (03) : 603 - 610
  • [3] 2,3-Dihydro-1H-1,5-benzodiazepines: A conversion of thiolactams to amidines
    Puodziunaite, B
    Kosychova, L
    Janciene, R
    Stumbreviciute, Z
    MONATSHEFTE FUR CHEMIE, 1997, 128 (12): : 1275 - 1281
  • [4] CHED 472-Synthesis of 2,3-dihydro-1H-1,5-benzodiazepines
    Conklin, Adrienne
    Yamaguchi, Kenneth
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 235
  • [5] Catalytic synthesis of 2,3-dihydro-1H-1,5-benzodiazepines by ferric perchlorate
    Heravi, Majid M.
    Zadsirjan, Vahideh
    Behbahani, Farahnaz K.
    Oskooie, Hossien A.
    JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2006, 259 (1-2) : 201 - 204
  • [6] PROPERTIES OF 2,2,4-TRISUBSTITUTED 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINES
    ORLOV, VD
    DESENKO, SM
    PIVNENKO, NS
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1987, (08): : 1122 - 1126
  • [7] SYNTHESIS AND PROPERTIES OF 2,2,4-TRISUBSTITUTED 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINES
    ORLOV, VD
    DESENKO, SM
    KOLOS, NN
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1984, (01): : 126 - 131
  • [8] A novel conversion of 2,4-diaryl-2,3-dihydro-1H-1,5-benzodiazepines into 2,4-diaryl-3H-1,5-benzodiazepines
    Zhang, QH
    Xu, JX
    CHINESE JOURNAL OF CHEMISTRY, 2001, 19 (04) : 378 - 380
  • [9] 2,3-Dihydro-1H-1,5-benzodiazepines: A conversion of thiolactams to amidines2,3-Dihydro-1H-1,5-benzodiazepine: Umwandlung von Thiolactamen in Amidine
    B. Puodžiūnaitė
    L. Kosychova
    R. Jančienė
    Z. Stumbrevičiūtė
    Monatshefte für Chemie / Chemical Monthly, 1997, 128 : 1275 - 1281
  • [10] Synthesis and antitumour activity of a series of cyclic amidines of 2,3-dihydro-1H-1,5-benzodiazepines
    Janciene, R
    Kosychova, L
    Bukelskiene, V
    Domkus, V
    Stumbreviciute, Z
    Ragaleviciene, V
    Puodziunaite, BD
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2002, 52 (06): : 475 - 481