Presynaptic facilitation: Quantal analysis and simulations

被引：2
|
作者：
Bykhovskaia, M [1 ]
Worden, MK [1 ]
Hackett, JT [1 ]
机构：
[1] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22903 USA
来源：
NEUROCOMPUTING | 1999年 / 26-7卷
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
neurosecretion; synaptic plasticity; modeling; electrophysiology;
D O I：
10.1016/S0925-2312(99)00083-1
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
The time-course of quantal neurosecretion indicated asynchrony in releases of presynaptic vesicles (quanta) in response to a stimulus. This was interpreted as reflecting the sequential release of vesicles from a single release site. We performed Monte-Carlo simulation of facilitated neurosecretion based upon the hypothesis that release sites do not limit transmitter release. The output of this simulation succeeded in reproducing the experimentally obtained distribution of quantal releases. These results support a. model for neurosecretion in which each action potential evokes mobilization of synaptic vesicles to a single presynaptic release site followed by probabilistic secretion of releasable vesicles one after another. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：9 / 15
页数：7
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