Synthesis of a tritium-labelled diether analog of phosphatidylinositol 4,5-bisphosphate

被引：0
|
作者：
Chen, J
Prestwich, GD
机构：
[1] Department of Chemistry, University at Stony Brook, Stony Brook
[2] Department of Medicinal Chemistry, University of Utah, 308 Skaggs Hall, Salt Lake City
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1997年 / 39卷 / 03期
关键词：
phosphoinositide; vesicles; binding assay; cell signalling; PtdIns(4,5)P-2;
D O I：
10.1002/(SICI)1099-1344(199703)39:3<251::AID-JLCR964>3.0.CO;2-Y
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of 1-(1,2-O-diundecyl-sn-glycerylphosphoryl) 4,5-D-myo-inosityl bisphosphate and its tritiated analog are described. The convergent synthesis employed optically-pure inositol and glycerol derivatives. In the final step, hydrogenation of an alkenyl chain gave the saturated diether PIP2 and tritiation gave the high-specific activity, tritium-labelled analog.
引用
收藏
页码：251 / 258
页数：8
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