Risk factors for gastrointestinal complications in aspirin users: Review of clinical and experimental data

被引：4
|
作者：
Leung, Felix W. [1 ,2 ]
机构：
[1] VA Greater Los Angeles Healthcare Syst, Sepulveda Ambulatory Care Ctr, Div Gastroenterol Res & Med Serv, Sepulveda, CA 91343 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
来源：
DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 10期
关键词：
aspirin; stomach; NSAID; smoking; alcohol; nitric oxide; nitroglycerin;
D O I：
10.1007/s10620-007-0178-6
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
This paper reviews recent clinical evidence that suggests that aspirin prophylaxis against cardiac and cerebral vascular ischemia is associated with significant gastrointestinal complications. The clinical and experimental evidence to confirm the role of risk factors of concomitant use of nonsteroidal anti-inflammatory drugs (NSAID), tobacco cigarette smoking, and alcohol consumption are discussed. The limitations of long-term acid suppression treatment for the prevention of these complications are considered. Future experimental studies to guide the clinical approach to develop novel and potentially cost-effective management strategies are discussed.
引用
收藏
页码：2604 / 2615
页数：12
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