Relapse of acute promyelocytic leukemia in the central nervous system revealed by isolated dementia

被引：0

作者：

Colin, O. ^{[1
]}

Julian, A. ^{[1
,2
]}

Puyade, M. ^{[3
]}

Bouyer, S. ^{[4
]}

Meurin, E. ^{[2
]}

Blondeau, S. ^{[2
]}

Houeto, J. L. ^{[1
,2
]}

Neau, J. P. ^{[1
,2
]}

机构：

[1] CHU Poitiers, Serv Neurol & Neuropsychol, F-86021 Poitiers, France

[2] CHU Poitiers, Ctr Memoire Ressources & Rech Poitou Charentes, 2 Rue Mil, F-86021 Poitiers, France

[3] CHU Poitiers, Serv Oncohematol, 2 Rue Mil, F-86021 Poitiers, France

[4] CHU Poitiers, Lab Hematol, 2 Rue Mil, F-86021 Poitiers, France

来源：

REVUE DE MEDECINE INTERNE | 2016年 / 37卷 / 12期

关键词：

Acute promyelocytic leukaemia; Relapse; Central nervous system; Dementia; TRANS-RETINOIC ACID; INVOLVEMENT;

D O I：

10.1016/j.revmed.2016.02.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction. - Approximately 1.5% of dementia is due to curable aetiology. We report an isolated dementia syndrome due to a meningeal relapse of acute promyelocytic leukaemia with favourable outcome after appropriate treatment. Case report. - A 72-year-old woman, in remission of an acute promyelocytic leukaemia, presented a loss of autonomy for several months due to corticosubcortical dementia. Lumbar puncture showed blast cells indicating meningeal relapse of leukaemia. Intrathecal chemotherapy and arsenic trioxide obtained biological and molecular remission as well as restoration of normal cognitive functions. Conclusion. - In patients with hematologic past history such as acute promyelocytic leukaemia, an isolated cognitive impairment should alert physicians to search for an isolated neuromeningeal relapse. (C) 2016 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：844 / 848

页数：5

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