Anaplastic lymphoma kinase-positive primary cutaneous anaplastic large cell lymphoma- Is it a new variant?

被引：12
|
作者：
Kumaran, Muthu Sendhil [1 ]
Jithendriya, Madhukara [2 ]
Nagaraj, Preethi [2 ]
Tirumalae, Rajalakshmi [3 ]
Jayaseelan, Elizabeth [2 ]
机构：
[1] PGIMER, Dept Dermatol Venerol & Leprol, Chandigarh, India
[2] St Johns Med Coll Hosp, Dept Dermatol, Bangalore, Karnataka, India
[3] St Johns Med Coll Hosp, Dept Pathol, Bangalore, Karnataka, India
来源：
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY | 2012年 / 78卷 / 03期
关键词：
Anaplastic lymphoma kinase; anaplastic large cell lymphoma; CD30; primary cutaneous lymphoma; TRANSLOCATION;
D O I：
10.4103/0378-6323.95454
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Anaplastic large cell cutaneous lymphomas are clinically and pathologically heterogeneous, CD30(+) (Ki-1) lymphoproliferative disorders. The importance of anaplastic lymphoma kinase (ALK) positivity is well known in the prognosis of primary systemic anaplastic large cell cutaneous lymphomas; however, the same in primary cutaneous anaplastic large cell cutaneous lymphomas is not much clear. Herein we report a 65-year-old male with an 18-month history of minimally pruritic localized nodulo-plaque lesion over lower back. Histology revealed cutaneous large cell lymphoma and immunohistochemical staining showed positivity for CD30, CD3 and ALK. The role of ALK positivity in pcALCL is discussed in this article.
引用
收藏
页码：354 / 357
页数：4
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