CD4+ T-Lymphocyte Count/CD8+ T-Lymphocyte Count Ratio: Surrogate for HIV Infection in Infants?

被引：0

作者：

Navaneethapandian, Poorana Ganga Devi ^{[1
]}

Karunaianantham, Ramesh ^{[1
]}

Subramanyan, Sudha ^{[1
]}

Chinnayan, Ponnuraja ^{[1
]}

Chandrasekaran, Padmapriyadarsini ^{[1
]}

Swaminathan, Soumya ^{[1
]}

机构：

[1] Indian Council Med Res, Natl Inst Res TB, Madras 600031, Tamil Nadu, India

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2012年 / 58卷 / 05期

关键词：

HIV; infants; surrogate marker; CD4; CD8; ratio; diagnosis; CELL RATIO; MORTALITY; DIAGNOSIS;

D O I：

10.1093/tropej/fmr102

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Methods: Two hundred and fifty-eight HIV-exposed Indian infants at a median age of 5 months (range 1-18) had DNA PCR and CD4, CD8 counts performed. Results: Fifty five infants tested positive by HIV-1 DNA PCR whereas 203 were negative. Median CD4 count, CD4% and CD4/CD8 ratio were significantly lower in DNA PCR+ infants. Overall sensitivity and specificity of CD4/CD8 ratio < 1.0 in predicting HIV was 91 and 92% with a negative predicted value (NPV) and positive predicted value (PPV) of 97 and 76%, respectively. Conclusion: CD4/CD8 ratio < 1.0 is a more sensitive surrogate marker of HIV infection in Indian infants than a CD4 count < 1500 cells/mu l or CD4% < 25%.

引用

页码：394 / 397

页数：4

共 50 条

[1] CD4 T-Lymphocyte Percentages Corresponding to CD4 T-Lymphocyte Count Thresholds in a New Staging System for HIV Infection
Selik, Richard M.
Gebo, Kelly A.
Borkowf, Craig B.
Whitmore, Suzanne K.
Espinoza, Lorena
[J]. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2014, 66 (04) : E92 - E94
[2] The CD4+ T-lymphocyte count is an important predictor for the prognosis of cryptococcosis
Ding, Y.
Li, P.
He, Q.
Wei, H.
Wu, T.
Xia, D.
Tan, M.
Shi, Y.
Su, X.
[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2017, 36 (05) : 897 - 904
[3] The CD4+ T-lymphocyte count is an important predictor for the prognosis of cryptococcosis
Y. Ding
P. Li
Q. He
H. Wei
T. Wu
D. Xia
M. Tan
Y. Shi
X. Su
[J]. European Journal of Clinical Microbiology & Infectious Diseases, 2017, 36 : 897 - 904
[4] CD4+ and CD8+ T-lymphocyte subsets in Zambian children
Ndhlovua, Z
Ryon, JJ
Griffin, DE
Monze, M
Kasolo, F
Moss, WJ
[J]. JOURNAL OF TROPICAL PEDIATRICS, 2004, 50 (02) : 94 - 97
[5] Correlation between T-lymphocyte CD4+ and Total Lymphocyte Count (TLC), hemoglobin, Neutrophil to Lymphocyte Ratio (NLR) and T-lymphocyte CD4+/CD8+ ratioin HIV patients at Prof. Dr. I.G.N.G Ngoerah Hospital, Denpasar, Bali, Indonesia
Prianggandanni, Made Ayu Vita
Lestari, Anak Agung Wiradewi
Wande, I. Nyoman
Mahartini, Ni Nyoman
Herawati, Sianny
[J]. BALI MEDICAL JOURNAL, 2023, 12 (02) : 2017 - 2021
[6] CD4+ CD8+ T-LYMPHOCYTE RATIO - EFFECTS OF REHYDRATION BEFORE EXERCISE IN DEHYDRATED MEN
GREENLEAF, JE
JACKSON, CGR
LAWLESS, D
[J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1995, 27 (02): : 194 - 199
[7] Computed tomographic demonstrations of HIV seropositive pulmonary tuberculosis and their relationship with CD4+ T-lymphocyte count
Zhang Yu-zhong
Li Hong-jun
Cheng Jing-liang
Wu Hao
Bao Dong-ying
[J]. CHINESE MEDICAL JOURNAL, 2011, 124 (05) : 693 - 698
[8] Computed tomographic demonstrations of HIV seropositive pulmonary tuberculosis and their relationship with CD4+ T-lymphocyte count
ZHANG Yuzhong
LI Hongjun
CHENG Jingliang
WU Hao
BAO Dongying
[J]. 中华医学杂志(英文版), 2011, (05) : 693 - 698
[9] Pulmonary tuberculosis in HIV infection: Radiographic appearance is related to CD4(+) T-lymphocyte count
Post, FA
Wood, R
Pillay, GP
[J]. TUBERCLE AND LUNG DISEASE, 1995, 76 (06): : 518 - 521
[10] Absolute CD4+ T-lymphocyte count as a surrogate marker of pediatric human immunodeficiency virus disease progression
Paintsil, Elijah
Ghebremichael, Musie
Romano, Sostena
Andiman, Warren A.
[J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2008, 27 (07) : 629 - 635

← 1 2 3 4 5 →