Inhibition of nitric oxide synthase by benzoxazolones

被引：29
|
作者：
Shankaran, K
Donnelly, KL
Shah, SK
Humes, JL
Pacholok, SG
Grant, SK
Green, BG
MacCoss, M
机构：
[1] MERCK RES LABS,DEPT IMMUNOL & INFLAMMAT,RAHWAY,NJ 07065
[2] MERCK RES LABS,DEPT ENZYMOL,RAHWAY,NJ 07065
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 22期
关键词：
D O I：
10.1016/S0960-894X(97)10101-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of benzoxazolones has been synthesized using modifications of literature methods. The synthetic benzoxazolone analogs, along with commercially available analogs, were evaluated as inhibitors of nitric oxide synthases (NOS). Structure-activity relationships are also discussed. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：2887 / 2892
页数：6
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