Correlation between antibodies and histology in celiac disease: Incidence of celiac disease is higher than expected in the pediatric population

被引:8
|
作者
Makovicky, Peter [1 ]
Rimarova, Kvetoslava [2 ]
Boor, Andrej [3 ]
Makovicky, Pavol [4 ]
Vodicka, Pavel [5 ]
Samasca, Gabriel [6 ]
Kruzliak, Peter [7 ]
机构
[1] Czech Univ Life Sci Prague, Dept Vet Sci, CZ-16521 Prague, Czech Republic
[2] Safarik Univ, Inst Publ Hlth, SK-04011 Kosice, Slovakia
[3] Safarik Univ, Inst Pathol, SK-04011 Kosice, Slovakia
[4] Selye Janos Univ, Dept Biol, SK-94501 Komarno, Slovakia
[5] Acad Sci Czech Republic, Inst Expt Med, Dept Mol Biol Canc, CZ-14220 Prague, Czech Republic
[6] Iuliu Hatieganu Univ Med & Pharm, Inst Immunol, RO-400177 Cluj Napoca, Romania
[7] Hosp Zvolen, Dept Pediat Gastroenterol, SK-96001 Zvolen, Slovakia
关键词
celiac disease; autoimmune disease; enterobiopsy; gluten-free diet; screening; GLUTEN-FREE DIET; TRANSGLUTAMINASE ANTIBODIES; TISSUE TRANSGLUTAMINASE; ANTIGLIADIN ANTIBODIES; ENDOMYSIUM ANTIBODIES; VILLOUS ATROPHY; SMALL-INTESTINE; BIOPSY; HISTOPATHOLOGY; SENSITIVITY;
D O I
10.3892/mmr.2013.1627
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The present study aims to report on the correlation between the degree of negativity of anti-endomysial antibodies and anti-tissue transglutaminase antibodies in the IgA and IgG classes with regard to histological grade, in 44 newly diagnosed children with celiac disease (CD). Samples with negative antibodies, but a positive histology from a 5-year program searching for CD in the pediatric population were collected. A total of 4247 biopsy samples were used in this study. We documented that certain pediatric patients are seronegative, while the disease is active and the incidence of CD is higher than expected in the pediatric population. This is an important finding, which demonstrates the lack of association between autoantibodies and lesions, and justifies the use of biopsies for an accurate CD diagnosis and the importance of revising the diagnostic criteria in a clinical, endoscopic and serological context. We recommend a more active search for incidences of the disease in the pediatric population. Serological markers are not the main method for the diagnosis of CD as they are considered to only have a supporting role clinically. Biopsies of the small intestine are always necessary for the diagnosis of CD in these patients.
引用
收藏
页码:1079 / 1083
页数:5
相关论文
共 50 条
  • [1] The Correlation Between Pediatric Intussusceptions and Celiac Disease
    Paul, Cassidy
    Anderson, Sharlette
    JOURNAL OF DIAGNOSTIC MEDICAL SONOGRAPHY, 2019, 35 (05) : 419 - 424
  • [2] Celiac Disease in the Pediatric Population
    Durham, Jessica
    Temples, Heide S.
    JOURNAL OF PEDIATRIC HEALTH CARE, 2018, 32 (06) : 627 - 631
  • [3] Celiac disease in the pediatric population
    Gelfond, D
    Fasano, A
    PEDIATRIC ANNALS, 2006, 35 (04): : 275 - 279
  • [4] TISSUE TRANSGLUTAMINASE ANTIBODIES IN CELIAC DISEASE: FOCUS ON THE PEDIATRIC POPULATION
    Hojsak, I.
    Shamir, R.
    DRUGS OF TODAY, 2011, 47 (09) : 683 - 691
  • [5] INCIDENCE OF CELIAC DISEASE AUTOIMMUNITY AND CELIAC DISEASE IN THE GENERAL POPULATION: TEDDY STUDY
    Gallant, Marisa L.
    Lee, Hye-Seung
    Hagopian, William
    Gragert, Loren
    Aronsson, Carin
    Lindfors, Katri
    Kurppa, Kalle
    Koletzko, Sibylle
    Ilonen, Jorma
    Rewers, Marian
    Agardh, Daniel
    Liu, Edwin
    GASTROENTEROLOGY, 2018, 154 (06) : S445 - S445
  • [6] Screening for celiac disease in a French adult population: Lower than expected prevalence
    不详
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 40 (05): : 639 - 639
  • [7] Incidence of Pediatric Celiac Disease Varies by Region
    Stahl, Marisa
    Li, Qian
    Lynch, Kristian
    Koletzko, Sibylle
    Mehta, Pooja
    Gragert, Loren
    Norris, Jill M.
    Aronsson, Carin Andren
    Lindfors, Katri
    Kurppa, Kalle
    Ilonen, Jorma
    Krischer, Jeffrey
    Alkolkar, Beena
    Ziegler, Anette-G
    Toppari, Jorma
    Rewers, Marian J.
    Agardh, Daniel
    Hagopian, William
    Liu, Edwin
    TEDDY Study Grp
    AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (03): : 539 - 545
  • [8] EVALUATION STUDY ON THE CORRELATION BETWEEN OPTICAL COHERENCE TOMOGRAPHY AND HISTOLOGY IN THE DIAGNOSIS OF CELIAC DISEASE IN PEDIATRIC PATIENTS
    Mangiavillavo, B.
    Masci, E.
    Albarello, L.
    Barera, G.
    Doglioni, C.
    Testoni, P. A.
    DIGESTIVE AND LIVER DISEASE, 2008, 40 : S92 - S92
  • [9] Evaluation study on the correlation between optical coherence tomography and histology in the diagnosis of celiac disease in pediatric patients
    Mangiavillano, Benedetto
    Masci, Enzo
    Albarello, Luca
    Doglioni, Claudio
    Parma, Barbara
    Barera, Graziano
    Alberto, Testoni Pier
    GASTROINTESTINAL ENDOSCOPY, 2008, 67 (05) : AB79 - AB79
  • [10] CELIAC DISEASE Diagnosis of celiac disease in pediatric patients
    Murray, Joseph A.
    Rashtak, Shadi
    Rubio-Tapia, Alberto
    NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2009, 6 (05) : 260 - 262