Analysis of the correlation between fetal growth restriction (FGR) and abnormal umbilical artery blood flow and the influencing factors on fetal growth. A total of 120 pregnant women with FGR admitted to our hospital from January 2016 to January 2019 were selected as study subjects in the observation group, while 100 normal pregnant women were recruited into the control group. The ratio of the systolic peak value to diastolic peak value (S/D), resistance index (RI) and pulsatility index (PI) of umbilical artery blood flow in the two groups were observed, since the elevation of these indexes indicates oxygen deficit and various factors that cause FGR were analyzed. The factors with statistical significance were included in the multivariate logistic regression analysis to analyze the independent risk factors of FGR. The S/D, PI and RI of the observation group were higher than those of the control group, and the differences were statistically significant (P<0.05). The S/D of the observation group decreased with the advance of gestational weeks, and was higher than that of the control group; the results of univariate and multivariate logistic regression analysis found that anemia, oligohydramnios, placental abnormality and umbilical cord abnormality were independent risk factors for FGR. When a fetus in the uterus develops a growth restriction, his/her umbilical artery blood flow will show clear abnormalities, and the resistance to blood flow will increase significantly. The anemia, oligohydramnios, placental abnormality, umbilical cord abnormality and fetal membrane abnormalities are independent risk factors for FGR. Attention has to be paid to pregnant women with such conditions in clinical practice.