A Neu View of Invasive Lobular Breast Cancer

被引：5
|
作者：
Bose, Ron [1 ,2 ]
机构：
[1] Washington Univ, Sch Med, Dept Med, Div Oncol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
来源：
CLINICAL CANCER RESEARCH | 2013年 / 19卷 / 13期
关键词：
MUTATIONS; DOMAIN; HER2; AMPLIFICATION; CARCINOMA; ERBB2;
D O I：
10.1158/1078-0432.CCR-13-1031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Genome sequencing of relapsed, invasive lobular breast cancer identified actionable mutations in 86% of the cases. HER2 alterations occur in 27% of the cases, including 4 cases with activating HER2 mutations and 1 with a novel HER2-GRB7 gene fusion. This fusion links the HER2 tyrosine kinase domain to the GRB7 src homology 2 (SH2) domain. (C)2013 AACR.
引用
收藏
页码：3331 / 3333
页数：3
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