EEG microstates as biomarker for psychosis in ultra-high-risk patients

被引：57
|
作者：
de Bock, Renate [1 ,2 ]
Mackintosh, Amatya J. [1 ,2 ]
Maier, Franziska [1 ]
Borgwardt, Stefan [1 ,3 ]
Riecher-Rossler, Anita [4 ]
Andreou, Christina [2 ]
机构：
[1] Univ Basel, Univ Psychiat Clin UPK Basel, Basel, Switzerland
[2] Univ Basel, Div Clin Psychol & Epidemiol, Dept Psychol, Basel, Switzerland
[3] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany
[4] Univ Basel, Fac Med, Basel, Switzerland
来源：
TRANSLATIONAL PSYCHIATRY | 2020年 / 10卷 / 01期
关键词：
CLINICAL HIGH-RISK; 1ST-EPISODE SCHIZOPHRENIA; STATE; DURATION; PREDICTION; NAIVE; INDIVIDUALS; TOPOGRAPHY; DYNAMICS; SALIENCE;
D O I：
10.1038/s41398-020-00963-7
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Resting-state EEG microstates are brief (50-100 ms) periods, in which the spatial configuration of scalp global field power remains quasi-stable before rapidly shifting to another configuration. Changes in microstate parameters have been described in patients with psychotic disorders. These changes have also been observed in individuals with a clinical or genetic high risk, suggesting potential usefulness of EEG microstates as a biomarker for psychotic disorders. The present study aimed to investigate the potential of EEG microstates as biomarkers for psychotic disorders and future transition to psychosis in patients at ultra-high-risk (UHR). We used 19-channel clinical EEG recordings and orthogonal contrasts to compare temporal parameters of four normative microstate classes (A-D) between patients with first-episode psychosis (FEP;n = 29), UHR patients with (UHR-T;n = 20) and without (UHR-NT;n = 34) later transition to psychosis, and healthy controls (HC;n = 25). Microstate A was increased in patients (FEP & UHR-T & UHR-NT) compared to HC, suggesting an unspecific state biomarker of general psychopathology. Microstate B displayed a decrease in FEP compared to both UHR patient groups, and thus may represent a state biomarker specific to psychotic illness progression. Microstate D was significantly decreased in UHR-T compared to UHR-NT, suggesting its potential as a selective biomarker of future transition in UHR patients.
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页数：9
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